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KMID : 0043319850080040237
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Archives of Pharmacal Research
1985 Volume.8 No. 4 p.237 ~ p.242
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Studies on Triterpenoid Corticominetics (VI) Anti-inflammatory Activities of 11-keto-deravatives of Pomolc Acid, beta-boswellic Acid and Presenegenin
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Han BH
Han YN/Park ET/Kim KM/Kim TH
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Abstract
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11-Keto-derivatives of pomolic acid, beta-boswellic acid and presenegenin were compared with those of oleanolic acid, hederagenin and glycyrrhetinic acid in respects of inhibitions on corticoid-5beta-reductase and anti-inflammatory activities. Hydrophilicity of ring A and hydrophobicity of rings C/D enhanced the inhibition on the enzyme. However, the former induced edema and the latter caused to exhibit anti-inflammatory activity.
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